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Ober, Carole

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overview	The research goals of my laboratory are to identify genetic variants that influence gene expression and epigenetic marks in tissues relevant to complex phenotypes and common diseases, in particular those related to asthma, allergy and preterm birth. To this end we are using both freshly isolated cells and tissues and cell culture models of gene-environment interactions to dissect the genetic architecture of common diseases. Our studies are conducted in founder populations, the Hutterites of South Dakota and the Amish of northern Indiana, in U.S. and European birth cohorts, and in patient populations from Chicago.

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overview

The research goals of my laboratory are to identify genetic variants that influence gene expression and epigenetic marks in tissues relevant to complex phenotypes and common diseases, in particular those related to asthma, allergy and preterm birth. To this end we are using both freshly isolated cells and tissues and cell culture models of gene-environment interactions to dissect the genetic architecture of common diseases. Our studies are conducted in founder populations, the Hutterites of South Dakota and the Amish of northern Indiana, in U.S. and European birth cohorts, and in patient populations from Chicago.

One or more keywords matched the following items that are connected to Ober, Carole

Item Type	Name
Concept	Abortion, Spontaneous
Concept	ABO Blood-Group System
Concept	Alleles
Concept	Computer Simulation
Concept	Base Sequence
Concept	Binding Sites
Concept	Endocrine System
Concept	Cross-Sectional Studies
Concept	Disease Susceptibility
Concept	Genes, Dominant
Concept	Genes, MHC Class II
Concept	Genes, Lethal
Concept	Genes, Recessive
Concept	Genetic Carrier Screening
Concept	Genes, MHC Class I
Concept	Multigene Family
Concept	Muscular Atrophy, Spinal
Concept	Molecular Sequence Data
Concept	Major Histocompatibility Complex
Concept	Selection, Genetic
Concept	Sexual Behavior
Concept	Sex Characteristics
Concept	Skin Tests
Concept	Social Isolation
Concept	Population Surveillance
Concept	Pseudogenes
Concept	Receptors, Cell Surface
Concept	Semen
Concept	Respiratory Syncytial Viruses
Concept	Cohort Studies
Concept	Regulatory Sequences, Nucleic Acid
Concept	Smoking
Concept	Seasons
Concept	Serotonin
Concept	Sensitivity and Specificity
Concept	Sheep
Concept	Smell
Concept	Synaptic Membranes
Concept	Software
Concept	Statistics as Topic
Concept	Stem Cells
Concept	Ultrasonography
Concept	United States
Concept	Urban Population
Concept	Transcription Initiation Site
Concept	Up-Regulation
Concept	Chi-Square Distribution
Concept	Mutagenesis, Site-Directed
Concept	Case-Control Studies
Concept	T-Lymphocyte Subsets
Concept	Alternative Splicing
Concept	Sequence Analysis, DNA
Concept	Prostate-Specific Antigen
Concept	Sequence Deletion
Concept	Genes, X-Linked
Concept	Serotonin Plasma Membrane Transport Proteins
Concept	Respiratory Syncytial Virus Infections
Concept	Sample Size
Concept	Genes, T-Cell Receptor
Concept	Calcium Signaling
Concept	P-Selectin
Concept	In Situ Hybridization, Fluorescence
Concept	Genetic Association Studies
Concept	Endosomal Sorting Complexes Required for Transport
Concept	Genetic Pleiotropy
Concept	Exome
Concept	Inducible T-Cell Co-Stimulator Protein
Concept	Histone Code
Concept	5' Untranslated Regions
Concept	Oligonucleotide Array Sequence Analysis
Concept	3' Untranslated Regions
Concept	Tumor Necrosis Factor Ligand Superfamily Member 15
Concept	Surveys and Questionnaires
Concept	Respiratory System
Concept	Severity of Illness Index
Concept	Myocytes, Smooth Muscle
Concept	South Dakota
Concept	Streptococcus pneumoniae
Concept	Ubiquitin-Protein Ligases
Concept	High-Throughput Nucleotide Sequencing
Concept	Sex Factors
Concept	Sinusitis
Concept	Models, Statistical
Concept	STAT2 Transcription Factor
Concept	Survival Analysis
Concept	Open Reading Frames
Concept	2',5'-Oligoadenylate Synthetase
Concept	Genome, Human
Concept	Stromal Cells
Concept	Statistics, Nonparametric
Concept	Genes, erbB-2
Concept	Tandem Repeat Sequences
Concept	Untranslated Regions
Concept	RNA, Untranslated
Concept	Transcriptome
Concept	Genome-Wide Association Study
Concept	Body Size
Concept	Suppressor of Cytokine Signaling Proteins
Concept	National Heart, Lung, and Blood Institute (U.S.)
Concept	National Institute of Allergy and Infectious Diseases (U.S.)
Concept	Metagenome
Concept	Survival of Motor Neuron 1 Protein
Concept	Data Interpretation, Statistical
Concept	Epistasis, Genetic
Concept	Follow-Up Studies
Concept	Rhinitis, Allergic, Seasonal
Concept	Health Status
Concept	Lod Score
Concept	Prospective Studies
Concept	Respiratory Sounds
Concept	Serine Endopeptidases
Concept	Sperm Motility
Concept	Umbilical Cord
Concept	Signal Transduction
Concept	Conserved Sequence
Concept	Sequence Analysis, RNA
Concept	Polymorphism, Single-Stranded Conformational
Concept	Polymorphism, Single Nucleotide
Concept	Quantitative Trait Loci
Concept	Scavenger Receptors, Class A
Concept	Sarcoplasmic Reticulum Calcium-Transporting ATPases
Concept	Genetic Loci
Academic Article	HLA-G1 protein expression is not essential for fetal survival.
Academic Article	Broad and narrow heritabilities of quantitative traits in a founder population.
Academic Article	Paternally inherited HLA alleles are associated with women's choice of male odor.
Academic Article	Quantitative-trait homozygosity and association mapping and empirical genomewide significance in large, complex pedigrees: fasting serum-insulin level in the Hutterites.
Academic Article	A null mutation in HLA-G is not associated with preeclampsia or intrauterine growth retardation.
Academic Article	A second-generation genomewide screen for asthma-susceptibility alleles in a founder population.
Academic Article	Novel case-control test in a founder population identifies P-selectin as an atopy-susceptibility locus.
Academic Article	Variation in the HLA-G promoter region influences miscarriage rates.
Academic Article	Sequence variation in the promoter region of the cholinergic receptor muscarinic 3 gene and asthma and atopy.
Academic Article	Are common disease susceptibility alleles the same in outbred and founder populations?
Academic Article	Genetic variation in immunoregulatory pathways and atopic phenotypes in infancy.
Academic Article	Genome-wide association study identifies ITGB3 as a QTL for whole blood serotonin.
Academic Article	The genetic dissection of complex traits in a founder population.
Academic Article	Linkage disequilibrium and age estimates of a deletion polymorphism (1597DeltaC) in HLA-G suggest non-neutral evolution.
Academic Article	Testing for Hardy-Weinberg equilibrium in samples with related individuals.
Academic Article	Human body scents: conscious perceptions and biological effects.
Academic Article	Sex-specific genetic architecture of whole blood serotonin levels.
Academic Article	Multilocus linkage disequilibrium mapping by the decay of haplotype sharing with samples of related individuals.
Academic Article	Cutting edge: polymorphisms in the ICOS promoter region are associated with allergic sensitization and Th2 cytokine production.
Academic Article	ITGB3 shows genetic and expression interaction with SLC6A4.
Academic Article	Evidence of balancing selection at the HLA-G promoter region.
Academic Article	Does HLA-dependent chimerism underlie the pathogenesis of juvenile dermatomyositis?
Academic Article	Heritability estimation of sex-specific effects on human quantitative traits.
Academic Article	Correlation of intergenerational family sizes suggests a genetic component of reproductive fitness.
Academic Article	High-resolution mapping of crossovers reveals extensive variation in fine-scale recombination patterns among humans.
Academic Article	Best linear unbiased allele-frequency estimation in complex pedigrees.
Academic Article	Sex-specific genetic architecture of human disease.
Academic Article	CFTR mutations and reproductive outcomes in a population isolate.
Academic Article	Variation in ITGB3 has sex-specific associations with plasma lipoprotein(a) and whole blood serotonin levels in a population-based sample.
Academic Article	Genome-wide association study of plasma lipoprotein(a) levels identifies multiple genes on chromosome 6q.
Academic Article	Colloquium papers: Heritability of reproductive fitness traits in a human population.
Academic Article	Sequencing the IL4 locus in African Americans implicates rare noncoding variants in asthma susceptibility.
Academic Article	HLA-G and immune tolerance in pregnancy.
Academic Article	Shades of gray: a comparison of linkage disequilibrium between Hutterites and Europeans.
Academic Article	The sex-specific genetic architecture of quantitative traits in humans.
Academic Article	Fine mapping and positional candidate studies on chromosome 5p13 identify multiple asthma susceptibility loci.
Academic Article	Gene-environment interactions in human disease: nuisance or opportunity?
Academic Article	Allele-specific targeting of microRNAs to HLA-G and risk of asthma.
Academic Article	Integrin beta 3 genotype influences asthma and allergy phenotypes in the first 6 years of life.
Academic Article	The genetics of asthma and allergic disease: a 21st century perspective.
Academic Article	IFNG genotype and sex interact to influence the risk of childhood asthma.
Academic Article	Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
Academic Article	Accurate imputation of rare and common variants in a founder population from a small number of sequenced individuals.
Academic Article	Genome-wide ancestry association testing identifies a common European variant on 6q14.1 as a risk factor for asthma in African American subjects.
Academic Article	Genetic analysis of HLA in the U.S. Schmiedenleut Hutterites.
Academic Article	Increased protein-coding mutations in the mitochondrial genome of African American women with preeclampsia.
Academic Article	Estimating the human mutation rate using autozygosity in a founder population.
Academic Article	Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases.
Academic Article	Adverse effects of human leukocyte antigen-DR sharing on fertility: a cohort study in a human isolate.
Academic Article	The combination of a genome-wide association study of lymphocyte count and analysis of gene expression data reveals novel asthma candidate genes.
Academic Article	Variation in conserved non-coding sequences on chromosome 5q and susceptibility to asthma and atopy.
Academic Article	Evaluating the evidence for transmission distortion in human pedigrees.
Academic Article	Sex-specific genetic architecture of asthma-associated quantitative trait loci in a founder population.
Academic Article	Rising prevalence of asthma is sex-specific in a US farming population.
Academic Article	Genome-wide association study identifies candidate genes for male fertility traits in humans.
Academic Article	Variation in ITGB3 is associated with whole-blood serotonin level and autism susceptibility.
Academic Article	Resequencing candidate genes implicates rare variants in asthma susceptibility.
Academic Article	HLA-DQA1 and HLA-DQB1 haplotypes in aborted fetuses and couples with recurrent spontaneous abortion.
Academic Article	MHC class II compatibility in aborted fetuses and term infants of couples with recurrent spontaneous abortion.
Academic Article	Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function.
Academic Article	Sequence variations at the human leukocyte antigen-linked olfactory receptor cluster do not influence female preferences for male odors.
Academic Article	Exome sequencing reveals a novel mutation for autosomal recessive non-syndromic mental retardation in the TECR gene on chromosome 19p13.
Academic Article	A population-based study of autosomal-recessive disease-causing mutations in a founder population.
Academic Article	Shared HLA antigens and reproductive performance among Hutterites.
Academic Article	HLA and mate choice in humans.
Academic Article	Estimation of variance components of quantitative traits in inbred populations.
Academic Article	Major loci influencing serum triglyceride levels on 2q14 and 9p21 localized by homozygosity-by-descent mapping in a large Hutterite pedigree.
Academic Article	Evidence for extensive transmission distortion in the human genome.
Academic Article	Association studies for asthma and atopic diseases: a comprehensive review of the literature.
Academic Article	Fine mapping and positional candidate studies identify HLA-G as an asthma susceptibility gene on chromosome 6p21.
Academic Article	Gene-environment interaction effects on the development of immune responses in the 1st year of life.
Academic Article	Variation in ITGB3 is associated with asthma and sensitization to mold allergen in four populations.
Academic Article	Rethinking genetic models of asthma: the role of environmental modifiers.
Academic Article	A genome-wide screen for hyposmia susceptibility Loci.
Academic Article	Fine mapping of a locus for nonsyndromic mental retardation on chromosome 19p13.
Academic Article	A genomewide screen for chronic rhinosinusitis genes identifies a locus on chromosome 7q.
Academic Article	A common spinal muscular atrophy deletion mutation is present on a single founder haplotype in the US Hutterites.
Academic Article	Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans.
Academic Article	Low fetal loss rates after ultrasound-proved viability in early pregnancy.
Academic Article	The miscarriage-associated HLA-G -725G allele influences transcription rates in JEG-3 cells.
Academic Article	HLA-G genotypes and pregnancy outcome in couples with unexplained recurrent miscarriage.
Academic Article	Maternal microchimerism protects against the development of asthma.
Academic Article	Rhinovirus wheezing illness and genetic risk of childhood-onset asthma.
Academic Article	The maternal HLA-G 1597?C null mutation is associated with increased risk of pre-eclampsia and reduced HLA-G expression during pregnancy in African-American women.
Academic Article	A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations.
Academic Article	Maternal asthma and microRNA regulation of soluble HLA-G in the airway.
Academic Article	Inbreeding effects on fertility in humans: evidence for reproductive compensation.
Academic Article	Genome-wide interaction studies reveal sex-specific asthma risk alleles.
Academic Article	Effect of inbreeding avoidance on Hardy-Weinberg expectations: examples of neutral and selected loci.
Academic Article	HLA-G polymorphisms: neutral evolution or novel function?
Academic Article	Population genetic studies of HLA-E: evidence for selection.
Academic Article	Population genetic studies of HLA-G: allele frequencies and linkage disequilibrium with HLA-A1.
Academic Article	Human leukocyte antigen matching and fetal loss: results of a 10 year prospective study.
Academic Article	Whole-genome sequencing of individuals from a founder population identifies candidate genes for asthma.
Academic Article	Evolutionary forward genomics reveals novel insights into the genes and pathways dysregulated in recurrent early pregnancy loss.
Academic Article	PRIMAL: Fast and accurate pedigree-based imputation from sequence data in a founder population.
Academic Article	Seasonal variation in human gut microbiome composition.
Academic Article	Genome-wide association study of lung function phenotypes in a founder population.
Academic Article	Host genetic variation influences gene expression response to rhinovirus infection.
Academic Article	Ethnic-specific associations of rare and low-frequency DNA sequence variants with asthma.
Academic Article	Genome-Wide Association Studies of the Human Gut Microbiota.
Academic Article	Genome-Wide Methylation Study Identifies an IL-13-induced Epigenetic Signature in Asthmatic Airways.
Academic Article	Leveraging gene-environment interactions and endotypes for asthma gene discovery.
Academic Article	Asthma Genetics in the Post-GWAS Era.
Academic Article	Expression Quantitative Trait Locus Mapping Studies in Mid-secretory Phase Endometrial Cells Identifies HLA-F and TAP2 as Fecundability-Associated Genes.
Academic Article	Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children.
Academic Article	Integrated analyses of gene expression and genetic association studies in a founder population.
Academic Article	DNA methylation in lung cells is associated with asthma endotypes and genetic risk.
Academic Article	Host genetic variation in mucosal immunity pathways influences the upper airway microbiome.
Award or Honor Receipt	Distinguished Service Professor
Award or Honor Receipt	Jonas Salk Health Leadership Award for Research
Award or Honor Receipt	John E. Salvaggio Memorial Lectureship
Award or Honor Receipt	Fellow
Award or Honor Receipt	Named Blum-Riese Professor
Award or Honor Receipt	Northwestern Obstetrics and Gynecology Award
Award or Honor Receipt	J. Christian Herr Award for Excellence in Basic or Applied Research in Reproductive Immunology
Grant	Prenatal Origins of Asthma
Grant	Mendelian Disease - Asthma Comorbidity to Find Subgroup-Specific Asthma Genes
Grant	Chronic Rhinosinusitis Integrative Studies Program (CRISP)
Grant	Children's Respiratory and Environmental Workgroup (CREW)
Grant	Cellular and Molecular Systems Biology of Pregnancy
Academic Article	Rare non-coding variants are associated with plasma lipid traits in a founder population.
Academic Article	Parent of origin gene expression in a founder population identifies two new candidate imprinted genes at known imprinted regions.
Academic Article	Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.
Academic Article	Immune development and environment: lessons from Amish and Hutterite children.
Academic Article	Global DNA methylation changes spanning puberty are near predicted estrogen-responsive genes and enriched for genes involved in endocrine and immune processes.
Academic Article	Parent-of-origin effects on quantitative phenotypes in a large Hutterite pedigree.
Academic Article	Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies.
Academic Article	Associations between fungal and bacterial microbiota of airways and asthma endotypes.
Academic Article	T-cell phenotypes are associated with serum IgE levels in Amish and Hutterite children.
Academic Article	Author Correction: Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations.
Academic Article	Associations of autozygosity with a broad range of human phenotypes.
Academic Article	Advances in asthma and allergic disease genetics: Is bigger always better?
Academic Article	Transcriptional programming and T cell receptor repertoires distinguish human lung and lymph node memory T cells.
Academic Article	Association of HLA-DRB1*09:01 with tIgE levels among African-ancestry individuals with asthma.
Academic Article	Club Cell TRPV4 Serves as a Damage Sensor Driving Lung Allergic Inflammation.
Academic Article	Association of respiratory allergy, asthma, and expression of the SARS-CoV-2 receptor ACE2.
Academic Article	Expression quantitative trait locus fine mapping of the 17q12-21 asthma locus in African American children: a genetic association and gene expression study.
Academic Article	Epigenome-wide association study of DNA methylation and adult asthma in the Agricultural Lung Health Study.
Academic Article	Epigenetic landscape links upper airway microbiota in infancy with allergic rhinitis at 6 years of age.
Academic Article	Cytokine-induced molecular responses in airway smooth muscle cells inform genome-wide association studies of asthma.
Academic Article	Transcriptome and regulatory maps of decidua-derived stromal cells inform gene discovery in preterm birth.
Academic Article	FUT2-ABO epistasis increases the risk of early childhood asthma and Streptococcus pneumoniae respiratory illnesses.
Academic Article	Two-stage genome-wide association study of chronic rhinosinusitis and disease subphenotypes highlights mucosal immunity contributing to risk.
Academic Article	Sex-specific differences in peripheral blood leukocyte transcriptional response to LPS are enriched for HLA region and X chromosome genes.
Academic Article	A-to-I editing of miR-200b-3p in airway cells is associated with moderate-to-severe asthma.
Academic Article	Longitudinal data reveal strong genetic and weak non-genetic components of ethnicity-dependent blood DNA methylation levels.
Academic Article	Chromosome 17q12-21 Variants Are Associated with Multiple Wheezing Phenotypes in Childhood.
Academic Article	Genome-wide association study identifies TNFSF15 associated with childhood asthma.
Academic Article	Extensive pleiotropism and allelic heterogeneity mediate metabolic effects of IRX3 and IRX5.
Academic Article	ESTIMATION AND INFERENCE IN METABOLOMICS WITH NON-RANDOM MISSING DATA AND LATENT FACTORS.
Academic Article	Establishment of human induced trophoblast stem-like cells from term villous cytotrophoblasts.
Academic Article	A functional genomics pipeline identifies pleiotropy and cross-tissue effects within obesity-associated GWAS loci.
Academic Article	Multiethnic genome-wide and HLA association study of total serum IgE level.
Academic Article	Multi-omics colocalization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus.
Academic Article	Asthma-associated genetic variants induce IL33 differential expression through an enhancer-blocking regulatory region.
Academic Article	Inducible expression quantitative trait locus analysis of the MUC5AC gene in asthma in urban populations of children.
Academic Article	Genome-wide study of early and severe childhood asthma identifies interaction between CDHR3 and GSDMB.
Academic Article	New Insights Relating Gasdermin B to the Onset of Childhood Asthma.
Academic Article	Fine-mapping studies distinguish genetic risks for childhood- and adult-onset asthma in the HLA region.
Academic Article	DNA methylation signatures in airway cells from adult children of asthmatic mothers reflect subtypes of severe asthma.
Academic Article	Genome-wide association and multi-omics studies identify MGMT as a novel risk gene for Alzheimer's disease among women.
Academic Article	African-specific alleles modify risk for asthma at the 17q12-q21 locus in African Americans.
Academic Article	Discerning asthma endotypes through comorbidity mapping.
Academic Article	Multi-omic association study identifies DNA methylation-mediated genotype and smoking exposure effects on lung function in children living in urban settings.
Academic Article	A functional genomics pipeline to identify high-value asthma and allergy CpGs in the human methylome.
Concept	Whole Genome Sequencing
Concept	Nedd4 Ubiquitin Protein Ligases
Grant	Airway inflammation and HLA-G in asthma
Grant	Positional Cloning of a 6p-linked Asthma Gene
Grant	Molecular Genetic Studies of Fertility in the Hutterites
Grant	Integrated genetic, omic, and immunologic studies to identify endotypes and novel drug targets for asthma and allergic diseases
Grant	COLLABORATIVE STUDY OF THE GENETICS OF ASTHMA (CSGA)
Grant	Training of Junior Faculty for Careers in Omics of Lung Diseases
Grant	CHARACTERIZING A 5P-LINKED BHR SUSCEPTIBILITY LOCUS
Grant	The EVE Asthma Genetics Consortium: Building Upon GWAS
Grant	Genomic Studies of Sex-Specific Architecture of Asthma-Associated Traits
Grant	THERAPIES FOR RECURRENT MISCARRIAGE: A RANDOMIZED STUDY
Academic Article	Single cell profiling at the maternal-fetal interface reveals a deficiency of PD-L1+?non-immune cells in human spontaneous preterm labor.
Academic Article	Asthma-protective agents in dust from traditional farm environments.
Academic Article	Epigenetic responses to rhinovirus exposure in airway epithelial cells are correlated with key transcriptional pathways in chronic rhinosinusitis.
Academic Article	Revealing polygenic pleiotropy using genetic risk scores for asthma.
Academic Article	Analytical challenges in omics research on asthma and allergy: A National Institute of Allergy and Infectious Diseases workshop.
Academic Article	Gene-based association study of rare variants in children of diverse ancestries implicates TNFRSF21 in the development of allergic asthma.

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